Ingredient
Arginine Silicate (Nitrosigine)
Research dose
1.5 g
Evidence: Weak Taken before training: what counts is the amount in the serving you take.
Every study used 1.5 g. They measured blood-vessel response and focus, not strength or endurance, and nearly all were funded by or run with the maker.
Sources
Kalman D, Harvey PD, Perez Ojalvo S, Komorowski J. Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults. Nutrients. 2016;8(11):736.
Supports the research dose. Where: Abstract: "ASI (1500 mg/day) was tested in two double-blind placebo-controlled crossover". Read the source, checked 7 Oct 2026.
Rogers JM, Gills J, Gray M. Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults. J Int Soc Sports Nutr. 2020;17:12.
Supports the research dose. Where: Abstract: "Nitrosigine (1.5 g)"; flow-mediated dilation 60 min later. Read the source, checked 7 Oct 2026.
In the pre-workouts we've checked
| Product | Per scoop | Verdict |
|---|---|---|
| NutraBio PRE | 750 mg | Below research dose |
| Bucked Up Mother Bucker | 1.5 g | Effective dose |
| Huge Supplements Pump Serum | 1.5 g | Effective dose |
| Beyond Raw LIT AF | 1.5 g | Effective dose |
| Beyond Raw LIT | 1.5 g | Effective dose |
| Nutricost Pre-X Workout Complex | 1.5 g | Effective dose |
| GAT Sport Nitraflex | In a blend | Hidden in a blend |
| Nutricost Pre-Workout Complex | 750 mg | Below research dose |
| ProSupps Mr. Hyde | 500 mg | Below research dose |
| RAW Nutrition CBUM Thavage | 750 mg | Below research dose |